A Challenging Opportunity for Obesity Researchers
Prof. Dr. Mohamed Elhashemy
August 07, 2009
In August 2009, a scientific research published online by the journal Science revealed that scientists have pinpointed a type of nerve cell in mice which appears to generate the itch sensation.
On the same principal, I think that a day will come soon, when researchers may find specific nerve cells responsible for stomach satiety, stimulation of which make them induce early satiety, while their suppression may induce overeating.
I believe that if researchers find a way to manipulate the neurons in gastric fundus mucosa, the same way they manipulated the neurons that are itch-specific, they may detect that these gastric fundus neurons are satiety-specific.
Since I have no research center to conduct this experiment, I invite interested researchers in the field of obesity management to perform the following informative experiment. They can apply a neurotoxin as bombesin-saporin, similar to what was used in the itch experiment to the gastric fundus mucosa of a group of mice; with the aim to knock out that cells, thus created satiety-free stomach. Afterwards, I expect that the mice will be no longer responding to any satiety stimuli, thus will not stop over eating, leading to obesity within short period.
If this research is done, it will prove that gastric fundus contain satiety-specific neurons with their axons passing through vagus nerve to the satiety center of hypothalamus. In 27 June 2008, I published an article in American Chronicle on this postulation, in which I called the spot containing these gastric fundus neurons: Elhashemy´s Stomach Satiety Spot "ESSS".
If the results of this research assured my postulation, the findings will have a very important therapeutic application in the field of obesity management. So, if we stimulate this stomach satiety spot before the main daily meal, this will result in great reduction of the total caloric intake for that meal and also for the whole day. This may prove to be a very effective tool in obesity management.
On the same principal, I think that a day will come soon, when researchers may find specific nerve cells responsible for stomach satiety, stimulation of which make them induce early satiety, while their suppression may induce overeating.
I believe that if researchers find a way to manipulate the neurons in gastric fundus mucosa, the same way they manipulated the neurons that are itch-specific, they may detect that these gastric fundus neurons are satiety-specific.
Since I have no research center to conduct this experiment, I invite interested researchers in the field of obesity management to perform the following informative experiment. They can apply a neurotoxin as bombesin-saporin, similar to what was used in the itch experiment to the gastric fundus mucosa of a group of mice; with the aim to knock out that cells, thus created satiety-free stomach. Afterwards, I expect that the mice will be no longer responding to any satiety stimuli, thus will not stop over eating, leading to obesity within short period.
If this research is done, it will prove that gastric fundus contain satiety-specific neurons with their axons passing through vagus nerve to the satiety center of hypothalamus. In 27 June 2008, I published an article in American Chronicle on this postulation, in which I called the spot containing these gastric fundus neurons: Elhashemy´s Stomach Satiety Spot "ESSS".
If the results of this research assured my postulation, the findings will have a very important therapeutic application in the field of obesity management. So, if we stimulate this stomach satiety spot before the main daily meal, this will result in great reduction of the total caloric intake for that meal and also for the whole day. This may prove to be a very effective tool in obesity management.
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